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KMID : 0358819850120010015
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Journal of Korean Society of Plastic and Reconstructive Surgeons
1985 Volume.12 No. 1 p.15 ~ p.22
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INHIBITION OF MYOFIBROBLASTS BY SKIN COVERAGE
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Cho Hyun-Chol
Lee Inn-Seung
Choi Hee-Youn
Kim Han-Jung
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Abstract
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The question of how skin coverage affects contracting wounds has long been a significant problem in the study of wound contraction.
Myofibroblasts appear to be well established as the cellular cause of wound contraction. Myofibroblasts are found in many types of contracting wounds, including granulating wounds and hypertrophic burn scars. Myofibroblasts in contracting wounds have definitive life cycles, being present when contraction is active and then disappearing when contraction has ceased.
In this study, we observated comparatively quantitative changes in the surface area by planimetry and changes of myofibroblasts by electron microscope through 8 weeks according to the types of skin coverage.
The purpose of this study was to evaluate the myofibroblast population in skin coveraged wounds in a rat model, which allowed frequent biopsies as well as precise identificaion of the interface of the skin coverage and the wound bed.
The results of our experiments are as follows:
1. Granulating wound
Contracted rapidly and had long persistence of myofibroblasts.
2. Split-thickness skin graft
Contrated less and myofibroblasts were more rapidly decreased and were disappeared at 5 weeks later.
3. Full-thickness skin graft
Minimum contracti aondnmyofibroblasts were very rapidly decreased and were disappeared at 4 weeks later.
4. Local flap
No contraction and could not find myofibroblast. Slowly increase in size at begining.
5. Contraction was influenced by number and lasting time of myofibroblast.
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KEYWORD
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